A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
نویسندگان
چکیده
منابع مشابه
Escherichia coli nucleoside diphosphate kinase does not act as a uracil-processing DNA repair nuclease.
Escherichia coli nucleoside diphosphate kinase (Ndk) catalyzes ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the cognate diphosphate precursor. Recently, the Ndk polypeptide was reported to be a multifunctional base excision repair nuclease that processed uracil residues in DNA by acting sequentially as a uracil-DNA glycosylase inhibitor protein (Ugi)-sensitive ura...
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The human SNM1A and SNM1B/Apollo proteins are members of an extended family of eukaryotic nuclease containing a motif related to the prokaryotic metallo-β-lactamase (MBL) fold. SNM1A is a key exonuclease during replication-dependent and transcription-coupled interstrand crosslink repair, while SNM1B/Apollo is required for maintaining telomeric overhangs. Here, we report the crystal structures o...
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Safeguarding the integrity of the genome should not be left to chance. Indeed, all organisms have highly effective mechanisms to detect and remove errors and lesions in DNA. DNA mismatch repair (MMR) serves as the final safeguard in assuring the fidelity of DNA replication from bacteria to humans and backstops the nucleotide selection and exonuclease proofreading activities of replicative polym...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2019
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c9ob01133a